Cover photograph (Copyright © 2008, American Society for Microbiology. All Rights Reserved.): Scanning electron microscopy image of a bloodstream form Trypanosoma brucei cell. A fraction of the cell surface is graphically removed to expose the underlying mitochondrion and kinetoplast region (mitochondrion, green; kinetoplast, blue; AEP-1, red; colocalization is indicated by yellow). Below the cell is the alternatively edited RNA sequence of AEP-1. Red U's indicate uridines that have been inserted during RNA editing; the two uridines highlighted in yellow mark the site of alternative editing. (See related article on p. 5595.)