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Mol Cell Biol. 1994 October; 14(10): 6464-6475

A striking similarity in the organization of the E-selectin and beta interferon gene promoters.

M Z Whitley, D Thanos, M A Read, T Maniatis and T Collins

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.

ABSTRACT

Transcription of the endothelial leukocyte adhesion molecule 1 (E-selectin or ELAM-1) gene is induced by the inflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha (TNF-alpha). In this report, we identify four positive regulatory domains (PDI to PDIV) in the E-selectin promoter that are required for maximal levels of TNF-alpha induction in endothelial cells. In vitro DNA binding studies reveal that two of the domains contain novel adjacent binding sites for the transcription factor NF-kappa B (PDIII and PDIV), a third corresponds to a recently described CRE/ATF site (PDII), and a fourth is a consensus NF-kappa B site (PDI). Mutations that decrease the binding of NF-kappa B to any one of the NF-kappa B binding sites in vitro abolished cytokine-induced E-selectin gene expression in vivo. Previous studies demonstrated a similar correlation between ATF binding to PDII and E-selectin gene expression. Here we show that the high-mobility-group protein I(Y) [HMG I(Y)] also binds specifically to the E-selectin promoter and thereby enhances the binding of both ATF-2 and NF-kappa B to the E-selectin promoter in vitro. Moreover, mutations that interfere with HMG I(Y) binding decrease the level of cytokine-induced E-selectin expression. The organization of the TNF-alpha-inducible element of the E-selectin promoter is remarkably similar to that of the virus-inducible promoter of the human beta interferon gene in that both promoters require NF-kappa B, ATF-2, and HMG I(Y). We propose that HMG I(Y) functions as a key architectural component in the assembly of inducible transcription activation complexes on both promoters.

Mol Cell Biol. 1994 October; 14(10): 6464-6475




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  • Pierce, J. W., Schoenleber, R., Jesmok, G., Best, J., Moore, S. A., Collins, T., Gerritsen, M. E. (1997). Novel Inhibitors of Cytokine-induced Ikappa Balpha Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo. J. Biol. Chem. 272: 21096-21103 [Abstract] [Full Text]  
  • Yao, J., Mackman, N., Edgington, T. S., Fan, S.-T. (1997). Lipopolysaccharide Induction of the Tumor Necrosis Factor-alpha Promoter in Human Monocytic Cells. REGULATION BY Egr-1, c-Jun, AND NF-kappa B TRANSCRIPTION FACTORS. J. Biol. Chem. 272: 17795-17801 [Abstract] [Full Text]  
  • Paxton, L. L. L., Li, L.-J., Secor, V., Duff, J. L., Naik, S. M., Shibagaki, N., Caughman, S. W. (1997). Flanking Sequences for the Human Intercellular Adhesion Molecule-1 NF-kappa B Response Element Are Necessary for Tumor Necrosis Factor alpha -Induced Gene Expression. J. Biol. Chem. 272: 15928-15935 [Abstract] [Full Text]  
  • Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., Collins, T. (1997). CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl. Acad. Sci. USA 94: 2927-2932 [Abstract] [Full Text]  
  • Introna, M., Mantovani, A. (1997). Early Activation Signals in Endothelial Cells: Stimulation by Cytokines. Arterioscler. Thromb. Vasc. Bio. 17: 423-428 [Abstract] [Full Text]  
  • Chen, X.-L. L., Tummala, P. E., Olliff, L., Medford, R. M. (1997). E-Selectin Gene Expression in Vascular Smooth Muscle Cells: Evidence for a Tissue-Specific Repressor Protein. Circ. Res. 80: 305-311 [Abstract] [Full Text]  
  • Oeth, P., Parry, G. C.N., Mackman, N. (1997). Regulation of the Tissue Factor Gene in Human Monocytic Cells: Role of AP-1, NF-{kappa}B/Rel, and Sp1 Proteins in Uninduced and Lipopolysaccharide-Induced Expression. Arterioscler. Thromb. Vasc. Bio. 17: 365-374 [Abstract] [Full Text]  
  • Read, M. A., Whitley, M. Z., Gupta, S., Pierce, J. W., Best, J., Davis, R. J., Collins, T. (1997). Tumor Necrosis Factor alpha -Induced E-selectin Expression Is Activated by the Nuclear Factor-kappa B and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways. J. Biol. Chem. 272: 2753-2761 [Abstract] [Full Text]  
  • Ollivier, V., Parry, G. C.N., Cobb, R. R., Prost, D. d., Mackman, N. (1996). Elevated Cyclic AMP Inhibits NF-kappa B-mediated Transcription in Human Monocytic Cells and Endothelial Cells. J. Biol. Chem. 271: 20828-20835 [Abstract] [Full Text]  
  • Gustafson, K. S., Ginder, G. D. (1996). Interferon-gamma Induction of the Human Leukocyte Antigen-E Gene Is Mediated through Binding of a Complex Containing STAT1alpha to a Distinct Interferon-gamma -responsive Element. J. Biol. Chem. 271: 20035-20046 [Abstract] [Full Text]  
  • Wang, D.-Z., Ray, P., Boothby, M. (1995). Interleukin 4-inducible Phosphorylation of HMG-I(Y) Is Inhibited by Rapamycin. J. Biol. Chem. 270: 22924-22932 [Abstract] [Full Text]  
  • Pan, J., McEver, R. P. (1995). Regulation of the Human P-selectin Promoter by Bcl-3 and Specific Homodimeric Members of the NF-kappaB/Rel Family. J. Biol. Chem. 270: 23077-23083 [Abstract] [Full Text]  
  • Ogram, S. A., Reeves, R. (1995). Differential Regulation of a Multipromoter Gene. J. Biol. Chem. 270: 14235-14242 [Abstract] [Full Text]  
  • Ledebur, H. C., Parks, T. P. (1995). Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells. J. Biol. Chem. 270: 933-943 [Abstract] [Full Text]  
  • Pellacani, A., Wiesel, P., Razavi, S., Vasilj, V., Feinberg, M. W., Chin, M. T., Reeves, R., Perrella, M. A. (2001). Down-regulation of High Mobility Group-I(Y) Protein Contributes to the Inhibition of Nitric-oxide Synthase 2 by Transforming Growth Factor-beta 1. J. Biol. Chem. 276: 1653-1659 [Abstract] [Full Text]  
  • Steer, J. H., Kroeger, K. M., Abraham, L. J., Joyce, D. A. (2000). Glucocorticoids Suppress Tumor Necrosis Factor-alpha Expression by Human Monocytic THP-1 Cells by Suppressing Transactivation through Adjacent NF-kappa B and c-Jun-Activating Transcription Factor-2 Binding Sites in the Promoter. J. Biol. Chem. 275: 18432-18440 [Abstract] [Full Text]  


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