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Molecular and Cellular Biology, August 2008, p. 4675-4687, Vol. 28, No. 15
0270-7306/08/$08.00+0     doi:10.1128/MCB.00338-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors{triangledown}

Melanie Hoser,1 Michaela R. Potzner,1 Julia M. C. Koch,1 Michael R. Bösl,2 Michael Wegner,1* and Elisabeth Sock1

Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen, Erlangen,1 Max-Planck-Institut für Neurobiologie, Martinsried, Germany2

Received 28 February 2008/ Returned for modification 23 March 2008/ Accepted 17 May 2008

The transcription factors Sox4 and Sox11 are important regulators of diverse developmental processes including heart, lung, pancreas, spleen, and B-cell development. Here we have studied the role of the related Sox12 as the third protein of the SoxC group both in vivo and in vitro. Despite widespread Sox12 expression during embryonic development, Sox12-deficient mice developed surprisingly normally, so that they were born alive, showed no gross phenotypic abnormalities, and were fertile in both sexes. Comparison with the related Sox4 and Sox11 revealed extensive overlap in the embryonic expression pattern but more uniform expression levels for Sox12, without sites of particularly high expression. All three Sox proteins furthermore exhibited comparable DNA-binding characteristics and functioned as transcriptional activators. Sox12 was, however, a relatively weak transactivator in comparison to Sox11. We conclude that Sox4 and Sox11 function redundantly with Sox12 and can compensate its loss during mouse development. Because of differences in expression levels and transactivation rates, however, functional compensation is not reciprocal.

* Corresponding author. Mailing address: Institut für Biochemie, Fahrstrasse 17, D-91054 Erlangen, Germany. Phone: 49 9131 85 24620. Fax: 49 9131 85 22484. E-mail: m.wegner{at}biochem.uni-erlangen.de

{triangledown} Published ahead of print on 27 May 2008.

Molecular and Cellular Biology, August 2008, p. 4675-4687, Vol. 28, No. 15
0270-7306/08/$08.00+0     doi:10.1128/MCB.00338-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Formeister, E. J., Sionas, A. L., Lorance, D. K., Barkley, C. L., Lee, G. H., Magness, S. T. (2009). Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium. Am. J. Physiol. Gastrointest. Liver Physiol. 296: G1108-G1118 [Abstract] [Full Text]  


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